Nintedanib - Indications, Dosage, Side Effects and Precautions

• Women of reproductive potential should use effective contraceptive measures during the nintedanib treatment that must continue for at least three months after the last dose of nintedanib to avoid risk to the unborn babies. • Stomach disturbances such as diarrhea, vomiting, and nausea can occur during nintedanib treatment, and patients with such symptoms and signs should be managed with adequate hydrati‍‍‍‍‍‍​​​‍​​​​​​on, and supportive medications to stop vomiting. • If nausea or vomiting becomes severe during the treatment, stop the treatment with nintedanib. • Patients should be carefully monitored during nintedanib therapy as nintedanib can cause an increased risk of bleeding and ulceration of the stomach or the intestine. • Liver function tests should be carried out regularly before initiating the treatment with nintedanib and monthly once for three months followed by once in three months. • The dose of nintedanib may either be reduced or the treatment stopped temporarily in case of elevated liver enzyme levels. • Heart function should be evaluated during the treatment as nintedanib can cause clotting in the blood vessels. Patients should be treated if any symptoms or signs of heart attack or chest pain develop.