Statin va cholesterol: Nhung dieu moi benh nhan can biet

Statin la mot trong nhung thuoc duoc nghien cuu ky luong nhat trong lich su y hoc. Tu khi lovastatin duoc chap thuan nam 1987, nhom thuoc nay da thay doi can ban viec quan ly benh tim mach bang cach giam cholesterol LDL hieu qua.

Statin uc che HMG-CoA reductase, enzym then chot trong tong hop cholesterol o gan. Gan bu dap bang cach tang thu the LDL, hut nhieu cholesterol LDL tu mau hon. Ket qua: giam LDL 30–55%. Statin cuong do cao (atorvastatin 40–80 mg, rosuvastatin 20–40 mg) giam LDL >=50%.

Dau co xay ra o 5–10% benh nhan, nhung benh co thuc su (<0,1%) va tieu co van (<0,01%) rat hiem. Hieu ung nocebo dong vai tro dang ke. Statin tang nhe nguy co dai thao duong typ 2 nhung loi ich tim mach vuot xa rui ro nay.

Bao cao dau co khong giai thich duoc, nuoc tieu sam mau hoac met moi bat thuong. Khong bao gio tu y ngung statin — ngung dot ngot co the tang nguy co tim mach.